Evidence
Evidence.
Ten declared compounds. Every dose defensible. Every claim traceable.
LIMINATE composes cognitive activation rituals under a single rule : we do not sell what a study does not support. What follows is the traceable ground of LUCID — ten actives, cited to primary peer-reviewed research, mechanism to dosage. Where the science is thin, we say so. This document is dated, signed, and kept.
Acetyl-L-Tyrosine
Tyrosine crosses the blood-brain barrier and is enzymatically converted to L-dopa, then dopamine — a neurotransmitter central to focus, motivation and stress resilience. The acetylated form (N-Acetyl-L-Tyrosine) is included for improved bioavailability under cognitive demand.
- Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999;48(2):203-9.
- Colzato LS, Jongkees BJ, Sellaro R, Hommel B. Working memory reloaded : tyrosine repletes updating in the N-back task. Front Behav Neurosci. 2013;7:200.
- Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands — A review. J Psychiatr Res. 2015;70:50-57.
L-Phenylalanine
Essential aromatic amino acid, precursor to tyrosine and by extension to catecholamines (dopamine, norepinephrine). Included as a slow-release complement to Acetyl-L-Tyrosine, sustaining catecholamine synthesis across the working window.
- Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr. 2007;137(6 Suppl 1):1539S-1547S.
Citicoline (CDP-Choline)
Endogenous compound that yields choline and cytidine on hydrolysis, supporting phospholipid synthesis (phosphatidylcholine), neural membrane integrity, and cholinergic transmission. Documented for attention and frontal-lobe bioenergetics.
- McGlade E, Locatelli A, Hardy J, Kamiya T, Morita M, Morishita K, Sugimura Y, Yurgelun-Todd D. Improved attentional performance following citicoline administration in healthy adult women. Food Nutr Sci. 2012;3(6):769-773.
- Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75.
- Alvarez XA, Laredo M, Corzo D, Fernández-Novoa L, Mouzo R, Perea JE, Daniele D, Cacabelos R. Citicoline improves memory performance in elderly subjects. Methods Find Exp Clin Pharmacol. 1997;19(3):201-10.
Uridine Monophosphate
Pyrimidine nucleotide that supports synthesis of phosphatidylcholine and other membrane phospholipids via the Kennedy pathway, complementing Citicoline. Preclinical models associate uridine repletion with increased dopamine release and synaptic protein density.
- Cansev M, Wurtman RJ, Sakamoto T, Ulus IH. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005;1058(1-2):101-108.
- Wang L, Pooler AM, Albrecht MA, Wurtman RJ. Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
Rhodiola Rosea
Arctic adaptogen documented for stress-related fatigue and mental endurance. Active markers rosavines and salidroside modulate the HPA axis and monoamine turnover under prolonged cognitive load.
- Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea) : traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-93.
- Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000;7(5):365-71.
- Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period. Phytomedicine. 2000;7(2):85-89.
Affron® Saffron Extract
Patented saffron (Crocus sativus) extract standardised to Lepticrosalides®, studied for mood stability and cognitive calm under pressure. Randomised placebo-controlled trials document effects on anxiety and depressive symptomatology within four weeks.
- Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017;33:58-64.
- Lopresti AL, Drummond PD, Inarejos-García AM, Prodanov M. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms : A randomised, double-blind, placebo-controlled study. J Affect Disord. 2018;232:349-357.
Anhydrous Caffeine
Trimethylxanthine, adenosine receptor antagonist. LUCID uses a controlled micro-dose (70 mg — approximately one espresso) precisely paired with L-Theanine in a 1:3.6 ratio, following the amplitude documented in the Owen et al. combined-effect literature.
- Nehlig A. Is caffeine a cognitive enhancer ? J Alzheimers Dis. 2010;20(Suppl 1):S85-94.
- Einother SJL, Giesbrecht T. Caffeine as an attention enhancer : reviewing existing assumptions. Psychopharmacology (Berl). 2013;225(2):251-74.
L-Theanine
Amino acid γ-glutamylethylamide native to Camellia sinensis. Documented for alpha-wave induction and attenuation of caffeine-induced arousal without loss of alertness. LUCID composes the 1:3.6 caffeine-to-theanine ratio scientifically reviewed by Owen et al.
- Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008;11(4):193-8. DOI:10.1179/147683008X301513
- Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17(Suppl 1):167-8.
- Camfield DA, Stough C, Farrimond J, Scholey AB. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood : a systematic review and meta-analysis. Nutr Rev. 2014;72(8):507-522.
Ginger Root Extract
Zingiber officinale root extract standardised for gingerols. Included at a supportive micro-dose for peripheral circulation and traditional adjuvant use in cognitive ritual preparations.
- Saenghong N, Wattanathorn J, Muchimapura S, Tongun T, Piyavhatkul N, Banchonglikitkul C, Kajsongkram T. Zingiber officinale improves cognitive function of the middle-aged healthy women. Evid Based Complement Alternat Med. 2012;2012:383062.
Piperine
Alkaloid from Piper nigrum (black pepper). Included at a functional micro-dose to enhance intestinal absorption of accompanying actives — the same mechanism documented for the +30-40% bioavailability shift in the Shoba et al. curcumin study.
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-6.
- Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O. Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol. 2008;46(9):3106-10.
The formula holds
because the reading holds.
Discover LUCID
Andreas C. · Founder & Signatory · Brussels · MMXXVI
What Founders Receive
The Original Chain
A place among the first 2500. When we reach 2500, the chain closes. It never re-opens.
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€80 every 4 weeks. Locked forever. On every LUCID drop and every future formula.
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Every drop before the public. Every new formula, at launch. No wait. No public queue.
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